By 1920 only three gaseous anaesthetics were widely used – nitrous oxide, diethyl ether (ether) and chloroform. The toxicity of chloroform was acknowledged, nitrous oxide did not induce deep anaesthesia, and ether was extremely inflammable, so in the 1920s there were good reasons to search for new anaesthetics. While my concern is with gaseous anaesthetics, I recognise that there were parallel developments in two related fields, that of topical or local anaesthetics, typified by the natural product cocaine and a host of synthetic substances, and injectable anaesthetics starting with opiates, then barbiturates and leading to modern materials such as propofol (2,6-diisopropylphenol).
...MoreBook Masanori Kaji; Yasu Furukawa; Hiroaki Tanaka; Yoshiyuki Kikuchi (2016) Transformation of Chemistry from the 1920s to the 1960s.
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